Paracetamol is one of the best known non-narcotic painkilling drugs. Although very widely available it has a high overdose potential. Large doses cause damage to the liver and kidneys. Regular alcohol drinkers even of moderate amounts may be less able to tolerate paracetamol and at higher risk of liver damage from high doses of the painkiller. About 300 people a year die from Paracetamol overdose.